Founded in 2002, the firm invests in early and late stage ventures, providing capital investments and customized business growth services to life sciences enterprises in the region. They focus on supporting companies in the biotechnology, diagnostics, healthcare IT, medical devices, and therapeutics sectors. With 52 investments made to date, their portfolio includes companies such as Cognition Therapeutics, Clinical Platform, ALung Technologies, and Carmell Therapeutics. Pittsburgh Life Sciences Greenhouse has had three notable exits and has raised two funds, the latest being PLSG Accelerator Fund II, which raised $5.2 million.