The organization operates as a pediatric palliative care center and offers three critical services: respite, transitional, and end of life care. The House is designed to resemble a family home, providing a nurturing environment with amenities like a fully staffed kitchen, playrooms, and family apartments. Their mission is to minimize suffering by addressing the physical, emotional, spiritual, and psychosocial needs of the entire family. They achieve this through strong collaboration between families, physicians, and their interdisciplinary team. Volunteers play a crucial role in helping the organization fulfill its commitment to children and families. George Mark Children's House was founded in 2004 and is based in San Leandro, California.