The firm, based in Philadelphia, Pennsylvania, invests in late-stage healthcare companies in the United States and Europe. Its partners and associates are former industry executives with operational and transactional experience. New Rhein compiles syndicates of investors who bring expertise and a network of relationships to support portfolio companies in development, regulatory processes, marketing, and contract manufacturing. The firm aims to help its portfolio companies build value propositions attractive to strategic partners. Previous investments have included ophthalmic pharmaceuticals, molecular diagnostics, and respiratory drug/device inhalers. New Rhein is a private equity investor targeting healthcare devices and supplies, pharmaceuticals, and biotechnology.