The firm, located in San Francisco, focuses on investing in startups in the medical field, particularly in areas such as cardiovascular disease, orthopedics and spine, ophthalmology, metabolic disorders, neuro-mediated disorders, oncology, and ophthalmic conditions. Synergy takes a synergistic approach with entrepreneurs, providing capital allocation and access to their network, technical, clinical, and operational expertise. They invest directly in private, early-stage medical device firms or emerging companies that are developing disruptive technologies to address unmet healthcare needs.