Based in New York, Proton Enterprises invests in startups primarily in the United States, with a focus on financial technology, IP commercialization, and health & fitness. The fund, established in 2012 by James Murphy and John D'Orazio, typically invests in deals ranging from 1 to 5 million dollars. Proton Enterprises is involved in 2-6 deals per year, often alongside sponsors such as Y Combinator, Ohio Third Frontier, and John D'Orazio. The fund prefers to invest in startups that are less than a year old and has had success in the fields of real-time and management information systems. Some notable portfolio startups include Cognovi Labs, Nikola, and WONDER.