Founded in 2005, St. Louis Arch Angels aims to provide financial support and expertise to early-stage companies with high growth potential. They invest in startups in the range of $1-5 million and typically participate in rounds with 3-4 participants. The fund has a preference for startups in the Medical Device and Biotechnology sectors. They have made successful investments in companies like Appistry, ImmunoPhotonics, and Euclises Pharmaceuticals. St. Louis Arch Angels hosts 10 meetings each year where members connect with entrepreneurs and consider investing in their companies. The network plays a vital role in the region's innovation ecosystem, filling the gap left by institutional venture capital firms.