Based in the United States, Commonwealth Seed Capital focuses on investing in startups in the medical and agriculture industries. With an average investment value of $5-10 million, the firm typically participates in rounds with 4-5 participants. Although the fund has a lower number of lead investments compared to other organizations, it has had successful exits in 2014. Commonwealth Seed Capital often co-invests with Kentucky Science and Technology Corporation (KSTC), Bluegrass Angels, and Yearling Fund II. The fund also receives subsequent rounds of funding from Tate & Lyle Ventures, Techstars, and Tech Coast Angels. Notable portfolio startups include TNG Pharmaceuticals, SentryHealth, and Allylix. The firm primarily invests in startups that are 2-3 years old and operates in the United States. Additionally, Commonwealth Seed Capital benefits from the support and resources provided by the Kentucky Cabinet for Economic Development, which encourages job creation and retention, new investment, and economic development in Kentucky.