Last deal

$107M

Amount

Series C

Stage

15.11.2022

Date

3

all rounds

$207M

Total amount

date founded

Financing round

General

About Company
Jnana Therapeutics is a biotech company that creates therapies to improve patients' lives.

Industry

Sector :

Subsector :

Keywords :

founded date

01.01.2017

Number of employees

Company Type

For Profit

Last funding type

Series C

IPO status

Private

Description

The Boston-based Jnana Therapeutics develops medicines using its drug discovery platform to target the solute carrier (SLC) family of transporters and cell's metabolic gates. The company's platform addresses therapeutic targets across immunometabolism, lysosomal function, and mucosal defense, where SLC transporters provide novel targets for immuno-oncology, inflammatory disorders, and neurological diseases. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases, immune-mediated diseases, and cancer. The company's lead program is a potential first-in-class oral approach, targeting an allosteric site on the phenylalanine transporter SLC6A19, for the treatment of phenylketonuria (PKU), a rare genetic metabolic disease. Jnana is backed by leading life science investors Bain Capital Life Sciences, RA Capital Management, Polaris Partners, Versant Ventures, Avalon Ventures, Pfizer Ventures, and AbbVie Ventures.
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People

Founders
5
John Throup
John Throup

John Throup

current job

Jnana Therapeutics
Jnana Therapeutics

organization founded

1

John Throup

Amir Nashat
Amir Nashat

Amir Nashat

Amir Nashat is a Managing Partner in Polaris’ Boston office. Amir joined Polaris in 2002 and focuses on investments in healthcare. Amir currently represents Polaris as a Member of the Board of Directors at AgBiome, aTyr Pharmaceuticals (NASDAQ: LIFE), BIND Therapeutics (NASDAQ: BIND), Fate Therapeutics (NASDAQ: FATE), Metacrine, Promedior Pharmaceuticals, Scholar Rock, Selecta Biosciences, and Syros Pharmaceuticals. Additionally, Amir has served as a Member of the Board of Directors at Adnexus Therapeutics (Bristol Myers Squibb), Athenix Corporation (Bayer), Avila Therapeutics (Celgene), Living Proof, Pervasis Therapeutics (Shire Pharmaceuticals), Receptos (Celgene) and Sun Catalytix (Lockheed Martin). At Living Proof and Sun Catalytix, Amir served as the company’s initial Chief Executive Officer. Amir serves on the Partners Innovation Fund and is a Catalyst of the Deshpande Center for Technological Innovation at MIT. Amir previously served on the Board of the New England Venture Capital Association. Amir has been named to the Forbes Midas List of “Top 100 Venture Capitalists.” Prior to joining Polaris, Amir completed his Ph.D. as a Hertz Fellow in Chemical Engineering at the Massachusetts Institute of Technology with a minor in Biology under the guidance of Dr. Robert Langer. Amir also earned both his M.S. degree and B.S. degree in Materials Science and Mechanical Engineering at the University of California, Berkeley.

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Amir Nashat

Stuart L. Schreiber
Stuart L. Schreiber

Stuart L. Schreiber

Stuart Schreiber's lab studies the science of therapeutics. Researchers in his group rely on human biology to identify therapeutic targets that have been validated prior to testing in humans, and chemistry and chemical biology to discover small molecules that modulate the targets in ways required to provide relief or protection from disease. Schreiber and his group members have discovered principles that underlie information transfer and storage in cells, specifically discoveries relating to signaling by the phosphatase calcineurin and kinase mTOR (demonstrating for the first time that drugs can result from the targeting of protein kinases and protein phosphatases), gene regulation by chromatin-modifying histone deacetylases, small-molecule dimerizers that activate cellular processes by enforced proximity, and small-molecule probes of challenging targets and processes (e.g., transcription factors, oncogenes, protein/protein interactions, transdifferentiation) that relate to human disease. Their work has contributed to diversity-oriented synthesis (DOS) and discovery-based small-molecule screening in an open data-sharing environment.

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H3 Biomedicine
H3 Biomedicine

organization founded

3

Stuart L. Schreiber

Joel Barrish
Joel Barrish

Joel Barrish

Joel came to Jnana from Achillion Pharmaceuticals, where he served as CSO. Most of Joel’s career was spent as a medicinal chemist in pharma, where he capped a 28-year career at Bristol-Myers Squibb by spending the last 5 years as Vice President and Head of Discovery Chemistry, working across all therapeutic areas. During his BMS career, Joel worked with teams responsible for advancing more than 40 compounds into clinical development, including Sprycel (dasatinib), which he co-invented. While at BMS, Joel and his colleagues made notable advances in the area of kinase inhibitor drug discovery, particularly in immunology and oncology. He is a co-author on over 130 peer reviewed publications and is a co-inventor on 40 issued U.S. patents. Joel received a Ph.D. in Organic Chemistry from Columbia University working with Professor W. Clark Still. He spent 5 years at Hoffmann La-Roche prior to moving to BMS.

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Jnana Therapeutics

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1

Joel Barrish

Employee Profiles
11
Douglas W. Pagán

Douglas W. Pagán

CFO & COO

John Throup

John Throup

Senior Vice President, Head of Development

Heather Smith Blanchette

Heather Smith Blanchette

VP Nonclinical Development

Peter Kutchukian

Principal scientist

Brian M. Cali

Brian M. Cali

Member Board Of Directors

Jing Li

Principal scientist

Joanne Kotz

Joanne Kotz

Co-Founder & President

Joel Barrish

Joel Barrish

Co-founder & CSO

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