The company uses directed evolution to modify heat-stable proteins from hot spring microbes, enabling them to develop new diagnostic capabilities faster than the industry standard. Their high-quality binding proteins are more stable and affordable than traditional reagents, and can be adapted to various diseases and test formats. Mantle Biotech aims to address pain points in the diagnostic industry by providing low-cost, accurate medical diagnostics to meet unmet medical needs. Founded in 2019, the company is headquartered in Cambridge, Massachusetts.